Rizatriptan: Fast relief for acute migraine attacks

Rizatriptan (brand name Maxalt) is a prescription medicine used to stop a migraine attack once it starts. It does not prevent future attacks. People choose it because it often works faster and with fewer side effects than older migraine drugs.

Dosage & how to take

Typical oral doses are 5 mg or 10 mg taken at the first sign of a migraine. If you get partial relief, your doctor may tell you to take a second dose 2 hours after the first. Do not exceed 30 mg in 24 hours (that’s three 10 mg doses) unless your prescriber says otherwise.

If you take propranolol for blood pressure or migraine prevention, your rizatriptan dose is usually limited (often to 5 mg at a time) because propranolol raises rizatriptan levels. Follow your doctor’s instructions carefully.

What to expect and practical tips

Rizatriptan works by narrowing blood vessels and blocking pain pathways in the brain, so many people feel relief within 30 to 60 minutes. For a faster option, an orally disintegrating tablet is available that melts on your tongue—useful if you feel nauseous or can’t swallow pills.

Take rizatriptan as soon as you can after symptoms begin. If your headache goes away and then comes back, the second dose can help, but don’t take extra doses beyond what your doctor allowed. Avoid alcohol while you’re taking it—alcohol can make side effects worse.

Don’t use rizatriptan to treat a headache that isn’t a migraine. If you’re unsure whether your pain is a migraine, check with a healthcare provider before taking it.

Side effects, warnings & interactions

Common side effects include dizziness, drowsiness, dry mouth, and mild chest tightness. Serious but rare risks include heart problems, stroke, or high blood pressure. If you have heart disease, uncontrolled hypertension, or a history of stroke or transient ischemic attack, rizatriptan is usually not recommended.

Avoid using rizatriptan within 24 hours of ergotamine-type drugs and avoid combining it with MAO inhibitors or certain antidepressants without medical advice, because of the risk of serotonin syndrome. Always tell your doctor about all medications you take, including SSRIs, SNRIs, and herbal products like St. John’s wort.

If you experience chest pain, severe shortness of breath, fainting, or sudden weakness or vision problems after taking rizatriptan, get emergency care right away.

Store tablets at room temperature, away from moisture and heat. Keep them out of reach of children and pets.

Rizatriptan needs a prescription. If you consider buying it online, use a licensed pharmacy that requires a valid prescription and has clear contact information. When in doubt, ask your doctor for a trusted source.

If you have questions about dosing, interactions, or whether rizatriptan is right for you, talk to your doctor or pharmacist. They can tailor advice to your health and other medicines you take.