Aripiprazole: What it does and how to use it safely

Aripiprazole is an antipsychotic used for conditions like schizophrenia, bipolar disorder, and sometimes added to antidepressants for major depression. It comes in pills, orally disintegrating tablets, and long-acting injections prescribed and given by a clinic. People choose aripiprazole when doctors want an option that often causes less sedation and fewer metabolic changes than some older antipsychotics.

How aripiprazole is used

Doctors pick aripiprazole for several reasons: to reduce hallucinations or delusions in psychosis, to control manic episodes, and as an add-on when antidepressants alone don’t work. Dosing depends on the condition, age, other meds, and how you respond. Many adults start low and increase slowly under medical supervision. Never adjust the dose on your own—talk to your prescriber first.

There’s also a monthly injectable form that helps people who have trouble taking pills every day. The injection is given at a clinic and needs a prescription and a plan from your healthcare team.

What to watch for: side effects, interactions, and safety tips

Common side effects include restlessness or akathisia (feeling unable to sit still), insomnia, dizziness, nausea, and some weight gain. Movement problems like tremors or stiffness can happen, though they’re usually milder than with older drugs. Serious but rare issues include very high fever, muscle rigidity, or severe changes in mood or thinking—these need immediate medical care.

Aripiprazole interacts with drugs that affect liver enzymes (CYP2D6 and CYP3A4). That means medicines like some antidepressants, anticonvulsants, or strong antibiotics can raise or lower aripiprazole levels. Always tell your doctor about every prescription, over-the-counter drug, and supplement you take.

Before starting, your provider may check weight, blood sugar, and cholesterol. During treatment, expect periodic check-ins for movement side effects and metabolic changes. If you’re pregnant, breastfeeding, or under 25, discuss risks and benefits with your clinician—some age groups can have higher risks for suicidal thoughts or other side effects.

Practical tips: take aripiprazole at the same time each day, with or without food. Avoid alcohol and be cautious with activities that require alertness until you know how the medicine affects you. Don’t stop suddenly—talk to your prescriber about tapering if you need to stop.

If you notice severe restlessness, uncontrolled movements, a sudden fever with stiff muscles, or new suicidal thoughts, contact a doctor or emergency services right away. For questions about cost, availability, or switching between pills and injections, your clinic or pharmacist can explain options that fit your routine.

Want more detailed info or links to trusted resources? Check your prescriber or pharmacist—this page is a quick, practical starting point, not a substitute for medical advice tailored to you.