NSAID Side Effects: What You Need to Know Before Taking Them

When you reach for NSAIDs, nonsteroidal anti-inflammatory drugs used to reduce pain, fever, and inflammation. Also known as non-opioid pain relievers, they’re one of the most common types of medication people take daily—for headaches, back pain, arthritis, or even a bad menstrual cramp. But just because they’re available over the counter doesn’t mean they’re harmless. Many people don’t realize that taking NSAIDs regularly can quietly damage your stomach, kidneys, or heart—even if you feel fine.

Common NSAIDs like ibuprofen, a widely used painkiller sold under brands like Advil and Motrin, naproxen, the active ingredient in Aleve, known for longer-lasting relief, and aspirin, used for pain but also for heart protection in low doses all carry the same risks. They block enzymes that protect your stomach lining, which is why stomach bleeding is one of the most serious side effects. People over 60, those with a history of ulcers, or anyone taking blood thinners are at higher risk. Even healthy adults can develop high blood pressure or kidney problems after long-term use. And it’s not just about dosage—timing matters. Taking NSAIDs on an empty stomach or mixing them with alcohol makes these risks worse.

What most people miss is that these side effects don’t always show up right away. A quiet stomach ache, unexplained swelling in your ankles, or feeling more tired than usual could be early signs. If you’ve been popping NSAIDs for weeks or months, it’s worth asking your doctor if there’s a safer option. Some people do better with acetaminophen for pain, while others need physical therapy or targeted treatments for chronic conditions. The posts below break down real comparisons between NSAIDs and their alternatives—like how naproxen stacks up against ibuprofen, why aspirin might be risky for some, and what to do if you’re already experiencing side effects. You’ll find clear, no-fluff advice on who should avoid these drugs, how to reduce harm if you must use them, and what other options actually work.